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Infections in infants can increase the risk of heart disease later in life

The concept of the heart of young myocarditis

A study conducted by the Murdoch Children’s Research Institute (MCRI) found that multiple infections in childhood could expose adults to a higher risk of heart disease, obesity, stroke, and type 2 diabetes.

A possible relationship has been discovered between infections in infants and the risk of cardiovascular disease

Newborns have a weakened immune system. As a result, they are significantly more vulnerable to certain diseases than older children and adults. Their new immune system is not developed enough to fight the bacteria, viruses and parasites that cause these infections.

Bacteria and viruses cause most infections in newborns. Newborns can get an infection before, during, and after birth. Shortly after birth, the baby’s immune system begins to mature, rapidly reducing the number of infections that the baby gets. However, the short period of vulnerability to infections could have serious consequences for the child’s future health.

Researchers have discovered a potential link between childhood infections and the risk of cardiovascular disease later in life, opening the door to targeted intervention. The study, led by the Murdoch Children’s Research Institute (MCRI) and published in Elif On May 10, 2022, he found that increased markers of inflammation and changes in metabolism (the way cells in the body process food into energy) in infants prone to infections were similar to those seen in adults at risk for cardiovascular disease.

According to Dr. Toby Mansell of the Murdoch Children’s Research Institute, the results suggest that childhood childhood infections may predispose adults to a higher risk of heart disease, obesity, stroke, and type 2 diabetes.

“We found that the risk of developing cardiovascular disease in adults could be accumulated from the beginning of life,” he said. We know that babies are prone to infections. This causes inflammation, a key cardiometabolic risk factor, but the relationship between infection, inflammation and metabolic profiles in early childhood remained under explored until this study.

The study involved 555 infants from the Barwon Infant Study, a collaborative project between Barwon Health, Murdoch Children’s and Deakin University, with infections in infants followed for 12 months.

Research has shown that high rates of infection in infants up to the age of 12 months have been associated with increased markers of inflammation and changes in metabolic profiles, which influence how the body processes fats, proteins and sugars.

Professor Murdoch for children, David Burgner, said the infection has been recognized as a potential contributor to cardiovascular disease, one of the leading causes of death in adults globally.

In Australia, cardiovascular disease accounts for a quarter of all deaths, with one person dying every 10 minutes. More than 4 million Australians have cardiovascular disease and someone is hospitalized with this disease every minute.

Professor Burgner said the research provided opportunities for early prevention measures, such as identifying the types of infection and children at highest risk and how these risks could be offset by simple interventions.

“The actions could include promoting breastfeeding, providing timely vaccinations and supporting families so that they can keep their children at home if they do not feel well with an infection,” he said.

Researchers from the Royal Children’s Hospital, the University of Melbourne, the Baker Institute for Heart and Diabetes, the Florey Institute for Neuroscience and Mental Health, Deakin University, Radboud University Medical Center, the University of Queensland, Barwon Health and Monash University also contributed. . to study.

Reference: “Early infection and proinflammatory, atherogenic metabolomics and lipidomic profiles in childhood: a population-based cohort study” by Toby Mansell, Richard Saffery, Satvika Burugupalli, Anne-Louise Ponsonby, Mimi LK Tang, Martin O’Hely, Siroon Bekkering , Adam Alexander T Smith, Rebecca Rowland, Sarath Ranganathan, Peter D Sly, Peter Vuillermin, Fiona Collier, Peter Meikle, David Burgner and Barwon Infant Study Investigator Group, May 10, 2022, Elif.
DOI: 10.7554 / eLife.75170

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