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MIT chemists are designing new light-powered catalysts that could help production

The new MIT Photoredox catalyst

MIT chemists have designed a new type of photoredox catalyst that could facilitate the incorporation of light-driven reactions into continuous-flow production processes. Polymeric catalysts could be used to cover the tubes and to perform chemical transformations on the reactants as they flow through the tube, as imagined in this digital artwork. Credit: Richard Liu

When coated on plastic tubes, catalysts could act on flowing chemicals, helping to synthesize drugs and other compounds.

A new type of photoredox catalyst, designed by[{” attribute=””>MIT chemists, may make it easier to incorporate light-driven reactions into continuous flow manufacturing processes. The key is their insolubility, which allows them to be used over and over again.

Light-driven chemical reactions provide a powerful tool for chemists developing novel methods of producing pharmaceuticals and other important molecules. Harnessing this light energy requires photoredox catalysts, which can absorb light and transfer the energy to a chemical reaction.

Now, MIT chemists have designed a new type of photoredox catalyst that could make it easier to incorporate light-driven reactions into manufacturing processes. Unlike most existing photoredox catalysts, the new class of materials is insoluble, so they can be used over and over again. Such catalysts could be used to coat tubing and perform chemical transformations on reactants as they flow through the tube.

A catalyst is a substance that speeds up a chemical reaction. Catalysis is the process of accelerating a reaction by using a catalyst. Photoredox catalysts work by absorbing photons and then using that light energy to power a chemical reaction.

“Being able to recycle the catalyst is one of the biggest challenges to overcome in terms of being able to use photoredox catalysis in manufacturing. We hope that by being able to do flow chemistry with an immobilized catalyst, we can provide a new way to do photoredox catalysis on larger scales,” says Richard Liu, an MIT postdoc and the joint lead author of the new study.

The new catalysts, which can be tuned to perform many different types of reactions, could also be incorporated into other materials including textiles or particles.

Timothy Swager, the John D. MacArthur Professor of Chemistry at MIT, is the senior author of the paper, which was published on May 27, 2022, in the journal Nature Communications. Sheng Guo, an MIT research scientist, and Shao-Xiong Lennon Luo, an MIT graduate student, are also authors of the paper.

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Hybrid Materials

Photoredox catalysts work by absorbing photons and then using that light energy to power a chemical reaction, analogous to how chlorophyll in plant cells absorbs energy from the sun and uses it to build sugar molecules.

Chemists have developed two main classes of photoredox catalysts, which are known as homogeneous and heterogeneous catalysts. Homogeneous catalysts usually consist of organic dyes or light-absorbing metal complexes. These catalysts are easy to tune to perform a specific reaction, but the downside is that they dissolve in the solution where the reaction takes place. This means they can’t be easily removed and used again.

Heterogeneous catalysts, on the other hand, are solid minerals or crystalline materials that form sheets or 3D structures. These materials do not dissolve, so they can be used more than once. However, these catalysts are more difficult to tune to achieve the desired reaction.

To combine the benefits of both of these types of catalysts, the researchers decided to embed the dyes that make up homogeneous catalysts into a solid polymer. For this application, the researchers adapted a plastic-like polymer with tiny pores that they had previously developed for performing gas separations. In this study, the researchers demonstrated that they could incorporate about a dozen different homogeneous catalysts into their new hybrid material, but they believe it could work more many more.

“These hybrid catalysts have the recyclability and durability of heterogeneous catalysts, but also the precise tunability of homogeneous catalysts,” Liu says. “You can incorporate the dye without losing its chemical activity, so, you can more or less pick from the tens of thousands of photoredox reactions that are already known and get an insoluble equivalent of the catalyst you need.”

The researchers found that incorporating the catalysts into polymers also helped them to become more efficient. One reason is that reactant molecules can be held in the polymer’s pores, ready to react. Additionally, light energy can easily travel along the polymer to find the waiting reactants.

“The new polymers bind molecules from solution and effectively preconcentrate them for reaction,” Swager says. “Also, the excited states can rapidly migrate throughout the polymer. The combined mobility of the excited state and partitioning of the reactants in the polymer make for faster and more efficient reactions than are possible in pure solution processes.”

Higher Efficiency

The researchers also showed that they could tune the physical properties of the polymer backbone, including its thickness and porosity, based on what application they want to use the catalyst for.

As one example, they showed that they could make fluorinated polymers that would stick to fluorinated tubing, which is often used for continuous flow manufacturing. During this type of manufacturing, chemical reactants flow through a series of tubes while new ingredients are added, or other steps such as purification or separation are performed.

Currently, it is challenging to incorporate photoredox reactions into continuous flow processes because the catalysts are used up quickly, so they have to be continuously added to the solution. Incorporating the new MIT-designed catalysts into the tubing used for this kind of manufacturing could allow photoredox reactions to be performed during continuous flow. The tubing is clear, allowing light from an LED to reach the catalysts and activate them.

“The idea is to have the catalyst coating a tube, so you can flow your reaction through the tube while the catalyst stays put. In that way, you never get the catalyst ending up in the product, and you can also get a lot higher efficiency,” Liu says.

The catalysts could also be used to coat magnetic beads, making them easier to pull out of a solution once the reaction is finished, or to coat reaction vials or textiles. The researchers are now working on incorporating a wider variety of catalysts into their polymers, and on engineering the polymers to optimize them for different possible applications.

Reference: “Solution-processable microporous polymer platform for heterogenization of diverse photoredox catalysts” by Richard Y. Liu, Sheng Guo, Shao-Xiong Lennon Luo and Timothy M. Swager, 27 May 2022, Nature Communications.
DOI: 10.1038/s41467-022-29811-6

The research was funded by the National Science Foundation and the KAUST Sensor Initiative.

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